What Is Depression?
8. Prognosis
MDD has significant potential mortality and morbidity due to the possibility of suicide, disruption in relationships, substance abuse, and absence from work. Seventy percent to 80% of individuals can achieve a significant reduction in symptoms with proper treatment. However, it is important to note that as many as 50% may not respond to the initial treatment trial.
At 1 year after diagnosis, 20% will continue to meet the criteria for MDD while an additional 40% will experience partial remission. The presence of psychotic symptoms and irritability before treatment may mean poorer outcomes. Based on the American Academy of Child and Adolescent Psychiatry, a history of dysthymia, anxiety disorders, a previous depressive episode, and subsyndromal symptoms of depression increases the risk of future depression. Those with late-onset depression have a poorer prognosis compared to younger patients.
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